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The antibody against MCTP2 was raised in rabbit using the Recombinant Human Multiple C2 and transmembrane domain-containing protein 2 protein (129-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against MCTP2 was raised in rabbit using the Recombinant Human Multiple C2 and transmembrane domain-containing protein 2 protein (129-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-04848A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MCTP2 |
| Target Synonyms | MCTP2Multiple C2 and transmembrane domain-containing protein 2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Multiple C2 and transmembrane domain-containing protein 2 protein (129-240AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6DN12 |
Uniprot Id
Q6DN12
Target Species
Human
Target Name
MCTP2
Target Full Name
Multiple C2 and transmembrane domain-containing protein 2
Target Function
Might play a role in the development of cardiac outflow tract.
Target Involvement
Heterozygosity for a 2.2-Mb deletion at chromosome 15q26.2, encompassing MCTP2, has been identified in a 10-year-old girl and her 3-year-old half brother, who had both coarctation of the aorta associated with dysmorphic features and ventricular septal defects. An intragenic MCTP2 duplication, leading to premature truncation (F697X) within the first transmembrane region of the protein, has also been observed in a male patient with a non-syndromic complex cardiac malformation involving coarctation, hypoplastic left heart, mitral atresia, bicuspid aortic valve and muscular ventricular septal defect. Although the link between left ventricular outflow tract malformations and MCTP2 could not be established, it has been proposed that defects in the MCTP2 gene may contribute to phenotype. This hypothesis is supported by the observation that Xenopus laevis embryos treated with MCTP2 morpholinos show no evidence of endocardial cushion formation at any level of the developing outflow tract (PubMed:23773997).
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
MCTP family
Target Synonyms
MCTP2Multiple C2 and transmembrane domain-containing protein 2
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