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The antibody against MED12 was raised in rabbit using the Synthesized peptide derived from internal of Human MED12. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC.
The antibody against MED12 was raised in rabbit using the Synthesized peptide derived from internal of Human MED12. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC.
$297.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using MED12 antibody.
| Cat.No | ADC-41850A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MED12 |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human MED12. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q93074 |
Uniprot Id
Q93074
Target Species
Human
Target Name
MED12
Target Full Name
Mediator of RNA polymerase II transcription subunit 12
Target Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Target Involvement
Opitz-Kaveggia syndrome (OKS); Lujan-Fryns syndrome (LUJFRYS); Ohdo syndrome, X-linked (OHDOX)
Target Subcellular Location
Nucleus.
Target Protein Families
Mediator complex subunit 12 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Activator recruited cofactor 240 kDa component; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; CAGH45; HOPA; KIAA0192; MED12; MED12_HUMAN; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; OPA containing protein; OPA-containing protein; Thyroid hormone receptor associated protein complex 230 kDa component; Thyroid hormone receptor-associated protein complex 230 kDa component; TNRC11; Trap230; Trinucleotide repeat containing gene 11 protein; Trinucleotide repeat-containing gene 11 protein
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