Rabbit anti-Human MED7 Polyclonal Antibody

Uniprot Id

O43513

Target Species

Human

Target Name

MED7

Target Full Name

Mediator of RNA polymerase II transcription subunit 7

Target Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Target Subcellular Location

Nucleus.

Target Protein Families

Mediator complex subunit 7 family

Target Synonyms

Activator recruited cofactor 34 kDa component; Activator-recruited cofactor 34 kDa component; ARC34; Cofactor required for Sp1 transcriptional activation subunit 9; Cofactor required for Sp1 transcriptional activation; subunit 9 (33kD); Cofactor required for Sp1 transcriptional activation; subunit 9; 33kDa; CRSP complex subunit 9; CRSP33; CRSP9; hMED7; MED7; MED7_HUMAN; Mediator complex subunit 7; Mediator of RNA polymerase II transcription subunit 7; MGC12284; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33

Target Background

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.