Rabbit anti-Human MEX3C Polyclonal Antibody

The antibody against MEX3C was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 484-659 of human MEX3C (NP_057710.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-06837A

Number

Cat.No	ADA-06837A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MEX3C
Target Synonyms	RKHD2; BM-013; MEX-3C; RNF194; MEX3C	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	SH-SY5Y	Application	ELISA, WB

Cat.No

ADA-06837A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MEX3C

Target Synonyms

RKHD2; BM-013; MEX-3C; RNF194; MEX3C

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

SH-SY5Y

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 484-659 of human MEX3C (NP_057710.3).	Target Species	Human
Immunogen Sequence	LPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS	Uniprot ID	Q5U5Q3

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 484-659 of human MEX3C (NP_057710.3).

Target Species

Human

Immunogen Sequence

LPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS

Uniprot ID

Q5U5Q3

Background Information

Uniprot Id

Q5U5Q3
Target Species

Human
Target Name

MEX3C
Target Full Name

RNA-binding E3 ubiquitin-protein ligase MEX3C
Target Function

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Target Involvement

Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.
Target Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
Target Tissue Specificity

Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.
Target Synonyms

BM 013; BM013; FLJ38871; Mex 3 homolog C C. elegans ; Mex 3, C. elegans, homolog of C; MEX 3C; MEX3C; MEX3C_HUMAN; Ring finger and KH domain containing 2 ; RING finger and KH domain containing protein 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RKHD2; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C; RNF194

Rabbit anti-Human MEX3C Polyclonal Antibody

Specifications

Immunogen Information

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