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The antibody against MGME1 was raised in rabbit using the Recombinant Human Mitochondrial genome maintenance exonuclease 1 protein (81-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against MGME1 was raised in rabbit using the Recombinant Human Mitochondrial genome maintenance exonuclease 1 protein (81-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-24438A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MGME1 |
| Target Synonyms | MGME1 antibody; C20orf72 antibody; DDK1Mitochondrial genome maintenance exonuclease 1 antibody; EC 3.1.-.- antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mitochondrial genome maintenance exonuclease 1 protein (81-260AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BQP7 |
Uniprot Id
Q9BQP7
Target Species
Human
Target Name
MGME1
Target Full Name
Mitochondrial genome maintenance exonuclease 1
Target Function
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.
Target Involvement
Mitochondrial DNA depletion syndrome 11 (MTDPS11)
Target Subcellular Location
Mitochondrion.
Target Protein Families
MGME1 family
Target Synonyms
MGME1; C20orf72; DDK1Mitochondrial genome maintenance exonuclease 1; EC 3.1.-.-
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