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The antibody against MGP was raised in rabbit using the Human MGP as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against MGP was raised in rabbit using the Human MGP as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$600.00
| Cat.No | ADC-47982A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MGP |
| Target Synonyms | Cell growth inhibiting gene 36 protein antibody; Cell growth-inhibiting gene 36 protein antibody; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX antibody; GIG36 antibody; Matrix Gla protein antibody; MGLAP antibody; MGP antibody; MGP_HUMAN antibody; NTI antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Human MGP | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P08493 |
Uniprot Id
P08493
Target Species
Human
Target Name
MGP
Target Full Name
Matrix Gla protein
Target Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Target Involvement
Keutel syndrome (KTLS)
Target Subcellular Location
Secreted.
Target Protein Families
Osteocalcin/matrix Gla protein family
Target Research Area
Developmental Biology, Signal Transduction
Target Synonyms
Cell growth inhibiting gene 36 protein; Cell growth-inhibiting gene 36 protein; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX; GIG36; Matrix Gla protein; MGLAP; MGP; MGP_HUMAN; NTI
Target Background
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
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