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The antibody against MIB2 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase MIB2 protein (1-128AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MIB2 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase MIB2 protein (1-128AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-03230A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MIB2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase MIB2 protein (1-128AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96AX9 |
Uniprot Id
Q96AX9
Target Species
Human
Target Name
MIB2
Target Full Name
E3 ubiquitin-protein ligase MIB2
Target Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Target Subcellular Location
Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.
Target Tissue Specificity
Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Target Synonyms
MIB2; SKD; ZZANK1; E3 ubiquitin-protein ligase MIB2; EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1
Target Background
The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.
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