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The antibody against MIOS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 556-875 of human MIOS (NP_061878.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MIOS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 556-875 of human MIOS (NP_061878.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00383A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MIOS |
| Target Synonyms | MIO; Sea4; Yulink; MIOS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, K-562, Mouse brain, Mouse testis, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 556-875 of human MIOS (NP_061878.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NXC5 | Immunogen Sequence |
Uniprot Id
Q9NXC5
Target Species
Human
Target Name
MIOS
Target Full Name
GATOR2 complex protein MIOS
Target Function
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.
Target Subcellular Location
Lysosome membrane.
Target Protein Families
WD repeat mio family
Target Synonyms
MIOS; GATOR complex protein MIOS; Missing oocyte meiosis regulator homolog
Target Background
Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex.
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