Rabbit anti-Human MLH3 Polyclonal Antibody

The antibody against MLH3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1190-1389 of human MLH3 (NP_055196.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00055A

Number

Cat.No	ADA-00055A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MLH3
Target Synonyms	HNPCC7; MLH3	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HCT116	Application	ELISA, WB

Cat.No

ADA-00055A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MLH3

Target Synonyms

HNPCC7; MLH3

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HCT116

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1190-1389 of human MLH3 (NP_055196.2).	Target Species	Human
Immunogen Sequence	QVLQQVDNKFIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEK	Uniprot ID	Q9UHC1

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1190-1389 of human MLH3 (NP_055196.2).

Target Species

Human

Immunogen Sequence

QVLQQVDNKFIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEK

Uniprot ID

Q9UHC1

Background Information

Uniprot Id

Q9UHC1
Target Species

Human
Target Name

MLH3
Target Full Name

DNA mismatch repair protein Mlh3
Target Function

Probably involved in the repair of mismatches in DNA.
Target Involvement

Hereditary non-polyposis colorectal cancer 7 (HNPCC7); Colorectal cancer (CRC)
Target Subcellular Location

Nucleus.
Target Protein Families

DNA mismatch repair MutL/HexB family
Target Tissue Specificity

Ubiquitous.
Target Synonyms

DNA mismatch repair protein Mlh3; HNPCC 7; HNPCC; HNPCC7; MGC138372; Mismatch repair gene MLH 3; Mismatch repair gene MLH3; MLH 3; MLH3; MLH3_HUMAN; MutL homolog 3 (E. coli); MutL homolog 3; MutL protein homolog 3; S240II117
Target Background

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Rabbit anti-Human MLH3 Polyclonal Antibody

Specifications

Immunogen Information

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