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The antibody against MLH3 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MLH3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against MLH3 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MLH3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
| Cat.No | ADC-35612A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MLH3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human MLH3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UHC1 |
Uniprot Id
Q9UHC1
Target Species
Human
Target Name
MLH3
Target Full Name
DNA mismatch repair protein Mlh3
Target Function
Probably involved in the repair of mismatches in DNA.
Target Involvement
Hereditary non-polyposis colorectal cancer 7 (HNPCC7); Colorectal cancer (CRC)
Target Subcellular Location
Nucleus.
Target Protein Families
DNA mismatch repair MutL/HexB family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
DNA mismatch repair protein Mlh3; HNPCC 7; HNPCC; HNPCC7; MGC138372; Mismatch repair gene MLH 3; Mismatch repair gene MLH3; MLH 3; MLH3; MLH3_HUMAN; MutL homolog 3 (E. coli); MutL homolog 3; MutL protein homolog 3; S240II117
Target Background
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
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