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The antibody against MMADHC was raised in rabbit using the Recombinant Human Methylmalonic aciduria and homocystinuria type D protein, mitochondrial protein (26-142AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against MMADHC was raised in rabbit using the Recombinant Human Methylmalonic aciduria and homocystinuria type D protein, mitochondrial protein (26-142AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-05403A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MMADHC |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Methylmalonic aciduria and homocystinuria type D protein, mitochondrial protein (26-142AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H3L0 |
Uniprot Id
Q9H3L0
Target Species
Human
Target Name
MMADHC
Target Full Name
Cobalamin trafficking protein CblD
Target Function
Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
Target Involvement
Methylmalonic aciduria and homocystinuria type cblD (MMAHCD)
Target Subcellular Location
Cytoplasm. Mitochondrion.
Target Tissue Specificity
Widely expressed at high levels.
Target Synonyms
C2orf25; cblD ; Chromosome 2 open reading frame 25; CL25022 ; Methylmalonic aciduria (cobalamin deficiency) cblD type; with homocystinuria ; Methylmalonic aciduria and homocystinuria type D protein; methylmalonic aciduria and homocystinuria type D protein; mitochondrial; mitochondrial; MMAD_HUMAN; Mmadhc; Protein C2orf25; mitochondrial
Target Background
This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.
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