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Rabbit anti-Human MMEL1 Polyclonal Antibody

The antibody against MMEL1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 350-450 of human MMEL1 (NP_258428.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05229A

The antibody against MMEL1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 350-450 of human MMEL1 (NP_258428.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-05229A ClonalityPolyclonal
Host SpeciesRabbitTarget NameMMEL1
Target SynonymsNL1; NL2; SEP; NEP2; MMEL2; NEPII; MMEL1FormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive Samples293T, OVCAR3ApplicationELISA, WB

Immunogen Information


Immunogen DescriptionA synthetic peptide corresponding to a sequence within amino acids 350-450 of human MMEL1 (NP_258428.2).Target SpeciesHuman
Immunogen SequenceNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAUniprot IDQ495T6
Background Information
  • Uniprot Id

    Q495T6

  • Target Species

    Human

  • Target Name

    MMEL1

  • Target Full Name

    Membrane metallo-endopeptidase-like 1

  • Target Function

    Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond.

  • Target Subcellular Location

    Membrane; Single-pass type II membrane protein. Secreted.

  • Target Protein Families

    Peptidase M13 family

  • Target Tissue Specificity

    Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.

  • Target Synonyms

    Mel transforming oncogene like 1; Membrane metallo endopeptidase like 1 ; Membrane metallo endopeptidase like 2; Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 2; MMEL1; MMEL1_HUMAN; NEP2; NEP2(m); NEP2(s); NEPII; Neprilysin 2; Neprilysin II; Neprilysin Like 1; Neprilysin-2; Neprilysin-2 secreted; Neprilysin-like Protease beta; Neprilysin-like Protease gamma; NL1; NL2; SEP; soluble form; Soluble secreted endopeptidase

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