Rabbit anti-Human MMP11 Monoclonal Antibody

The antibody against MMP11 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 389-488 of human MMP11 (P24347) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-15993A

Number

Cat.No	ADA-15993A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	MMP11
Target Synonyms	ST3; SL-3; STMY3; MMP11	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, 293T, A549, MCF7, Mouse lung, Mouse testis, Rat testis	Application	ELISA, WB

Cat.No

ADA-15993A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

MMP11

Target Synonyms

ST3; SL-3; STMY3; MMP11

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, 293T, A549, MCF7, Mouse lung, Mouse testis, Rat testis

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 389-488 of human MMP11 (P24347).	Target Species	Human
Immunogen Sequence	AALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL	Uniprot ID	P24347

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 389-488 of human MMP11 (P24347).

Target Species

Human

Immunogen Sequence

AALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL

Uniprot ID

P24347

Background Information

Uniprot Id

P24347
Target Species

Human
Target Name

MMP11
Target Full Name

Stromelysin-3
Target Function

May play an important role in the progression of epithelial malignancies.
Target Subcellular Location

Secreted, extracellular space, extracellular matrix.
Target Protein Families

Peptidase M10A family
Target Tissue Specificity

Specifically expressed in stromal cells of breast carcinomas.
Target Synonyms

Matrix Metalloproteinase 11; Matrix metalloproteinase-11; MMP-11; Mmp11; MMP11_HUMAN; SL 3; SL-3; SL3; ST3; STMY3; Stromelysin 3; Stromelysin III; Stromelysin-3
Target Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Rabbit anti-Human MMP11 Monoclonal Antibody

Specifications

Immunogen Information

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