Rabbit anti-Human MMP25 Polyclonal Antibody

Uniprot Id

Q9NPA2

Target Species

Human

Target Name

MMP25

Target Full Name

Matrix metalloproteinase-25

Target Function

May activate progelatinase A.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Target Protein Families

Peptidase M10A family

Target Tissue Specificity

Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.

Target Research Area

Cancer

Target Synonyms

Leukolysin; matrix metallopeptidase 25; matrix metallopeptidase like 1; matrix metalloproteinase 20; Matrix Metalloproteinase 25; Matrix metalloproteinase 25 precursor; Matrix metalloproteinase-25; Membrane type 6 Matrix Metalloproteinase; Membrane type Matrix Metalloproteinase 6 ; Membrane-type matrix metalloproteinase 6; Membrane-type-6 matrix metalloproteinase; MMP 25; MMP-25; MMP20; MMP20A; MMP25; MMP25_HUMAN; MMPL1; MT MMP 6; MT-MMP 6; MT6 MMP; MT6-MMP; MT6MMP; MTMMP6

Target Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.