Rabbit anti-Human MMP26 Polyclonal Antibody

Uniprot Id

Q9NRE1

Target Species

Human

Target Name

MMP26

Target Full Name

Matrix metalloproteinase-26

Target Function

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Peptidase M10A family

Target Tissue Specificity

Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.

Target Synonyms

MMP26; Matrix metalloproteinase-26; MMP-26; EC 3.4.24.-; Endometase; Matrilysin-2

Target Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers.