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The antibody against MMP8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 101-467 of human MMP8 (NP_002415.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against MMP8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 101-467 of human MMP8 (NP_002415.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-10751A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MMP8 |
| Target Synonyms | HNC; CLG1; MMP-8; PMNL-CL; MMP8 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, HepG2, Jurkat | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 101-467 of human MMP8 (NP_002415.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P22894 | Immunogen Sequence |
Uniprot Id
P22894
Target Species
Human
Target Name
MMP8
Target Full Name
Neutrophil collagenase
Target Function
Can degrade fibrillar type I, II, and III collagens.
Target Subcellular Location
Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules.
Target Protein Families
Peptidase M10A family
Target Tissue Specificity
Neutrophils.
Target Research Area
Cancer
Target Synonyms
CLG 1; CLG1; Collagenase 1; Collagenase 1 neutrophil; HNC; Matrix metallopeptidase 8 (neutrophil collagenase); Matrix metalloprotease 8; Matrix metalloproteinase-8; MMP 8; MMP-8; Mmp8; MMP8_HUMAN; Neutrophil collagenase; PMNL CL; PMNL collagenase; PMNL-CL; PMNLCL
Target Background
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
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