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The antibody against MOCS3 was raised in rabbit using the Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3 protein (279-404aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against MOCS3 was raised in rabbit using the Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3 protein (279-404aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: MCF-7 whole cell lysate, PC-3 whole cell lysate, Mouse Liver tissue | All lanes: MOCS3 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 50 kDa | Observed band size: 50 kDa
| Cat.No | ADC-55017A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MOCS3 |
| Target Synonyms | MOCS3, Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)], UBA4 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3 protein (279-404aa) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95396 |
Uniprot Id
O95396
Target Species
Human
Target Name
MOCS3
Target Full Name
Adenylyltransferase and sulfurtransferase MOCS3
Target Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Target Subcellular Location
Cytoplasm.
Target Protein Families
HesA/MoeB/ThiF family, UBA4 subfamily
Target Synonyms
Adenylyltransferase MOCS3; dJ914P20.3; MGC9252; MOCS 3; MOCS3; MOCS3_HUMAN; Molybdenum cofactor synthesis 3; Molybdenum cofactor synthesis protein 3; Molybdopterin synthase sulfurylase; Molybdopterin-synthase sulfurtransferase; MPT synthase sulfurylase; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3; UBA 4; UBA4 ubiquitin activating enzyme E1 homolog; UBA4
Target Background
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.
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