Rabbit anti-Human MORF4L2 Polyclonal Antibody

Uniprot Id

Q15014

Target Species

Human

Target Name

MORF4L2

Target Full Name

Mortality factor 4-like protein 2

Target Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Target Subcellular Location

Nucleus.

Target Synonyms

KIAA0026 ; MO4L2_HUMAN; MORF related gene X protein; MORF-related gene X protein; Morf4l2; MORFL2; Mortality Factor 4 like 2; Mortality factor 4 like protein 2; Mortality factor 4-like protein 2; MRGX; MSL3 2 protein; Protein MSL3-2; Transcription factor like protein MRGX ; Transcription factor-like protein MRGX

Target Background

Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleolus; nucleoplasm; and plasma membrane.