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The antibody against MPI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human MPI (NP_002426.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MPI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human MPI (NP_002426.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09345A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MPI |
| Target Synonyms | PMI; PMI1; CDG1B; MPI | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, HepG2, Jurkat, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human MPI (NP_002426.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P34949 | Immunogen Sequence |
Uniprot Id
P34949
Target Species
Human
Target Name
MPI
Target Full Name
Mannose-6-phosphate isomerase
Target Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Target Involvement
Congenital disorder of glycosylation 1B (CDG1B)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Mannose-6-phosphate isomerase type 1 family
Target Tissue Specificity
Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
Target Research Area
Signal Transduction
Target Synonyms
MI1; CDG1B; FLJ39201; Mannose 6 phosphate isomerase; Mannose-6-phosphate isomerase; MANNOSEPHOSPHATE ISOMERASE; MGC94106; MPI; MPI_HUMAN; Phosphohexomutase; phosphomannose isomerase 1; Phosphomannose isomerase; PMI
Target Background
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants.
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