Rabbit anti-Human MPZL1 Polyclonal Antibody

Uniprot Id

O95297

Target Species

Human

Target Name

MPZL1

Target Full Name

Myelin protein zero-like protein 1

Target Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Myelin P0 protein family

Target Tissue Specificity

Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appe

Target Synonyms

MPZL1; PZR; UNQ849/PRO1787; Myelin protein zero-like protein 1; Protein zero-related

Target Background

Predicted to enable structural molecule activity. Predicted to be involved in cell-cell signaling and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within positive regulation of cell migration. Located in cell surface and focal adhesion.