Rabbit anti-Human MRPL23 Polyclonal Antibody

Uniprot Id

Q16540

Target Species

Human

Target Name

MRPL23

Target Full Name

Large ribosomal subunit protein uL23m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uL23 family

Target Synonyms

L23MRP; 39S ribosomal protein L23; 39S ribosomal protein L23; mitochondrial; L23 mitochondrial-related protein; L23mt; mitochondrial; Mitochondrial ribosomal protein L23; MRP-L23; MRPL23; Ribosomal protein L23-like; Ribosomal protein related to L23 (mitochondrial); RM23_HUMAN; RPL23; RPL23L

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.