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The antibody against MRPL3 was raised in rabbit using the Recombinant Human 39S ribosomal protein L3, mitochondrial protein (201-348AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against MRPL3 was raised in rabbit using the Recombinant Human 39S ribosomal protein L3, mitochondrial protein (201-348AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human liver cancer using MRPL3 Antibody at dilution of 1:1002
| Cat.No | ADC-24394A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MRPL3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human 39S ribosomal protein L3, mitochondrial protein (201-348AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P09001 |
Uniprot Id
P09001
Target Species
Human
Target Name
MRPL3
Target Full Name
Large ribosomal subunit protein uL3m
Target Involvement
Combined oxidative phosphorylation deficiency 9 (COXPD9)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Universal ribosomal protein uL3 family
Target Synonyms
39S ribosomal protein L3; 39S ribosomal protein L3 mitochondrial; COXPD9; L3mt; Mitochondrial 39S ribosomal protein L3; Mitochondrial 60S ribosomal protein L3; mitochondrial; mitochondrial ribosomal protein; Mitochondrial ribosomal protein L3; MRL3; MRP-L3; MRPL3; RM03_HUMAN; RPML3
Target Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.
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