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The antibody against MSH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 697-936 of human MSH4 (NP_002431.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MSH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 697-936 of human MSH4 (NP_002431.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05877A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MSH4 |
| Target Synonyms | ASG; POF20; SPGF2; MSH4 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 697-936 of human MSH4 (NP_002431.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O15457 | Immunogen Sequence |
Uniprot Id
O15457
Target Species
Human
Target Name
MSH4
Target Full Name
MutS protein homolog 4
Target Function
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
Target Subcellular Location
Chromosome.
Target Protein Families
DNA mismatch repair MutS family
Target Tissue Specificity
Testis and ovary specific.
Target Synonyms
hMSH4; MSH 4; MSH4; MSH4_HUMAN; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4
Target Background
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
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