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The antibody against MSH4 was raised in rabbit using the Fusion protein of Human MSH4 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against MSH4 was raised in rabbit using the Fusion protein of Human MSH4 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-31651A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MSH4 |
| Target Synonyms | hMSH4 antibody; MSH 4 antibody; MSH4 antibody; MSH4_HUMAN antibody; MutS homolog 4 (E. Coli) antibody; MutS homolog 4 antibody; MutS protein homolog 4 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Fusion protein of Human MSH4 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15457 |
Uniprot Id
O15457
Target Species
Human
Target Name
MSH4
Target Full Name
MutS protein homolog 4
Target Function
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
Target Subcellular Location
Chromosome.
Target Protein Families
DNA mismatch repair MutS family
Target Tissue Specificity
Testis and ovary specific.
Target Synonyms
hMSH4; MSH 4; MSH4; MSH4_HUMAN; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4
Target Background
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
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