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The antibody against MSRB3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-192 of human MSRB3 (Q8IXL7) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MSRB3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-192 of human MSRB3 (Q8IXL7) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-13280A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MSRB3 |
| Target Synonyms | DFNB74; MSRB3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat heart, A-549, Jurkat, Mouse testis, Rat lung, U2OS | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 50-192 of human MSRB3 (Q8IXL7). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | LRKRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSETKFDSGSGWPSFHDVINSEAITFTDDFSYGMHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSAALSFTPADSSGTAEGGSGVASPAQADKAEL | Uniprot ID | Q8IXL7 |
Uniprot Id
Q8IXL7
Target Species
Human
Target Name
MSRB3
Target Full Name
Methionine-R-sulfoxide reductase B3
Target Function
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
Target Involvement
Deafness, autosomal recessive, 74 (DFNB74)
Target Subcellular Location
[Isoform 1]: Endoplasmic reticulum.; [Isoform 2]: Mitochondrion.
Target Protein Families
MsrB Met sulfoxide reductase family
Target Tissue Specificity
Widely expressed.
Target Research Area
Signal Transduction
Target Synonyms
Deafness, Autosomal Recessive 74; DFNB74; FLJ36866; Methionine R sulfoxide reductase B mitochondrial; Methionine sulfoxide reductase B3; Methionine-R-sulfoxide reductase B3; MsrB3; MSRB3_HUMAN
Target Background
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
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