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The antibody against MSTN was raised in rabbit using the Recombinant Human Growth/differentiation factor 8 protein (267-375AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against MSTN was raised in rabbit using the Recombinant Human Growth/differentiation factor 8 protein (267-375AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-50323A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MSTN |
| Target Synonyms | Cmpt antibody; GDF-8 antibody; GDF8_HUMAN antibody; Growth/differentiation factor 8 antibody; MSLHP antibody; MSTN antibody; MSTN myostatin antibody; Myostatin antibody; Myostatin Propeptide antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Growth/differentiation factor 8 protein (267-375AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14793 |
Uniprot Id
O14793
Target Species
Human
Target Name
MSTN
Target Full Name
Growth/differentiation factor 8
Target Function
Acts specifically as a negative regulator of skeletal muscle growth.
Target Involvement
Muscle hypertrophy (MSLHP)
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Research Area
Signal Transduction
Target Synonyms
Cmpt; GDF-8; GDF8_HUMAN; Growth/differentiation factor 8; MSLHP; MSTN; MSTN myostatin; Myostatin; Myostatin Propeptide
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.
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