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The antibody against MT-ND1 was raised in rabbit using the Synthesized peptide derived from internal of Human MT-ND1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against MT-ND1 was raised in rabbit using the Synthesized peptide derived from internal of Human MT-ND1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Western blot analysis of extracts from A549 cells and COLO cells, using MT-ND1 antibody.
Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using MT-ND1 antibody.2
| Cat.No | ADC-41098A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MT-ND1 |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human MT-ND1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P03886 |
Uniprot Id
P03886
Target Species
Human
Target Name
MT-ND1
Target Full Name
NADH-ubiquinone oxidoreductase chain 1
Target Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Target Involvement
Leber hereditary optic neuropathy (LHON); Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS); Alzheimer disease mitochondrial (AD-MT); Diabetes mellitus, non-insulin-dependent (NIDDM); Mitochondrial complex I deficiency (MT-C1D)
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
Complex I subunit 1 family
Target Synonyms
Complex I; subunit ND1; Mitochondrially encoded NADH dehydrogenase 1; MT-ND1; MTND1 ; NAD1 ; NADH dehydrogenase subunit 1 (complex I) ; NADH dehydrogenase subunit 1; NADH-ubiquinone oxidoreductase chain 1; NADH-ubiquinone oxidoreductase; subunit ND1; NADH1 ; ND1 ; NU1M_HUMAN
Target Background
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial membrane. Part of mitochondrial respiratory chain complex I. Implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Parkinson's disease; and multiple sclerosis.
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