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The antibody against MT2A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-61 of human MT2A (NP_005944.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against MT2A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-61 of human MT2A (NP_005944.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-12151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MT2A |
| Target Synonyms | MT2; MT-2; MT-II; MT2A | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Jurkat, Rat testis | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-61 of human MT2A (NP_005944.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA | Uniprot ID | P02795 |
Uniprot Id
P02795
Target Species
Human
Target Name
MT2A
Target Full Name
Metallothionein-2
Target Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Target Protein Families
Metallothionein superfamily, Type 1 family
Target Synonyms
MT2A; CES1; MT2; Metallothionein-2; MT-2; Metallothionein-2A; Metallothionein-II; MT-II
Target Background
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer.
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