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The antibody against MTHFR was raised in rabbit using the Recombinant Human Methylenetetrahydrofolate reductase protein (1-656AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against MTHFR was raised in rabbit using the Recombinant Human Methylenetetrahydrofolate reductase protein (1-656AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-24322A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MTHFR |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Methylenetetrahydrofolate reductase protein (1-656AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P42898 |
Uniprot Id
P42898
Target Species
Human
Target Name
MTHFR
Target Full Name
Methylenetetrahydrofolate reductase (NADPH)
Target Function
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Target Involvement
Methylenetetrahydrofolate reductase deficiency (MTHFRD); Ischemic stroke (ISCHSTR); Neural tube defects, folate-sensitive (NTDFS); Schizophrenia (SCZD)
Target Protein Families
Methylenetetrahydrofolate reductase family
Target Research Area
Metabolism
Target Synonyms
5 10 methylenetetrahydrofolate reductase (NADPH); 5 10 methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase (NAD(P)H); Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase intermediate form; MTHFR; MTHR_HUMAN
Target Background
The protein encoded by this gene catalyzes the conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.
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