Rabbit anti-Human MUC20 Polyclonal Antibody

Uniprot Id

Q8N307

Target Species

Human

Target Name

MUC20

Target Full Name

Mucin-20

Target Function

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

Target Subcellular Location

Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.

Target Tissue Specificity

Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with th

Target Synonyms

MUC 20; MUC-20; Muc20; MUC20_HUMAN; Mucin 20; Mucin 20, cell surface associated; Mucin-20; Transmembrane mucin MUC20S

Target Background

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified.