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The antibody against MVB12A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MVB12A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04732A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MVB12A |
| Target Synonyms | CFBP; FAM125A; MVB12A | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat pancreas | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96EY5 | Immunogen Sequence |
Uniprot Id
Q96EY5
Target Species
Human
Target Name
MVB12A
Target Full Name
Multivesicular body subunit 12A
Target Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
Target Subcellular Location
Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with F-actin. Some fraction may be nuclear.
Target Protein Families
MVB12 family
Target Tissue Specificity
Ubiquitously expressed except in skeletal muscle.
Target Synonyms
MVB12A; CFBP; FAM125A; Multivesicular body subunit 12A; CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; Protein FAM125A
Target Background
Enables lipid binding activity and ubiquitin binding activity. Involved in regulation of epidermal growth factor receptor signaling pathway; viral budding; and virus maturation. Located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Part of ESCRT I complex.
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