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The antibody against MXD1 was raised in rabbit using the Human MXD1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against MXD1 was raised in rabbit using the Human MXD1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-47900A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MXD1 |
| Target Synonyms | MAD antibody; MAD protein antibody; MAD1 antibody; MAD1_HUMAN antibody; MAX dimerization protein 1 antibody; Max dimerizer 1 antibody; Mxd1 antibody; Protein MAD antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human MXD1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q05195 |
Uniprot Id
Q05195
Target Species
Human
Target Name
MXD1
Target Full Name
Max dimerization protein 1
Target Function
Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Target Subcellular Location
Nucleus.
Target Synonyms
MAD; MAD1; BHLHC58; MXD1
Target Background
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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