Rabbit anti-Human MYH2 Polyclonal Antibody, FITC conjugated

Uniprot Id

Q9UKX2

Target Species

Human

Target Name

MYH2

Target Full Name

Myosin-2

Target Function

Muscle contraction. Required for cytoskeleton organization.

Target Involvement

Myopathy, proximal, and ophthalmoplegia (MYPOP)

Target Subcellular Location

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Target Synonyms

adult 2; Fast 2a myosin heavy chain; IBM3; Inclusion body myopathy 3, autosomal dominant; MYH2; MYH2_HUMAN; MYH2A; MYHas8; MyHC IIa; MyHC-2a; MyHC-IIa; MYHSA2; Myosin heavy chain 2; Myosin heavy chain 2a; Myosin heavy chain; Myosin heavy chain IIa; Myosin heavy chain skeletal muscle adult 2; Myosin heavy polypeptide 2 skeletal muscle adult; Myosin-2; MYPOP; skeletal muscle; Type IIA myosin heavy chain

Target Background

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.