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The antibody against MYO5B was raised in rabbit using the Recombinant Human Unconventional myosin-Vb protein (1440-1690AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against MYO5B was raised in rabbit using the Recombinant Human Unconventional myosin-Vb protein (1440-1690AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MYO5B Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue using MYO5B Antibody at dilution of 1:1002
| Cat.No | ADC-16639A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MYO5B |
| Target Synonyms | KIAA1119 antibody; Myo5b antibody; MYO5B_HUMAN antibody; Myosin Vb antibody; Unconventional myosin-Vb antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Unconventional myosin-Vb protein (1440-1690AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULV0 |
Uniprot Id
Q9ULV0
Target Species
Human
Target Name
MYO5B
Target Full Name
Unconventional myosin-Vb
Target Function
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
Target Involvement
Diarrhea 2, with microvillus atrophy (DIAR2)
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Target Synonyms
KIAA1119; Myo5b; MYO5B_HUMAN; Myosin Vb; Unconventional myosin-Vb
Target Background
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease.
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