Rabbit anti-Human MYPN Polyclonal Antibody

Uniprot Id

Q86TC9

Target Species

Human

Target Name

MYPN

Target Full Name

Myopalladin

Target Function

Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.

Target Involvement

Nemaline myopathy 11 (NEM11); Cardiomyopathy, dilated 1KK (CMD1KK); Cardiomyopathy, familial hypertrophic 22 (CMH22); Cardiomyopathy, familial restrictive 4 (RCM4)

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line.

Target Protein Families

Myotilin/palladin family

Target Tissue Specificity

Expressed in adult skeletal muscle and fetal heart.

Target Synonyms

145 kDa sarcomeric protein; MYOP; Myopalladin; MYPN; MYPN_HUMAN; sarcomeric protein myopalladin

Target Background

Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants.