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The antibody against NALCN was raised in rabbit using the Recombinant Human Sodium leak channel non-selective protein (19-141AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against NALCN was raised in rabbit using the Recombinant Human Sodium leak channel non-selective protein (19-141AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
Immunofluorescent analysis of HepG2 cells using NALCN Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-15223A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NALCN |
| Target Synonyms | non selective antibody; Vgcnl1 antibody; VGCNL1 protein antibody; voltage gated channel like 1 antibody; Voltage gated channel-like protein 1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sodium leak channel non-selective protein (19-141AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IZF0 |
Uniprot Id
Q8IZF0
Target Species
Human
Target Name
NALCN
Target Full Name
Sodium leak channel NALCN
Target Function
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability. Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability.
Target Involvement
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1 (IHPRF1); Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD)
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Cation-nonselective channel family
Target Synonyms
A530023G15Rik; bA430M15.1; CanIon; Canlon; FLJ23913 ; FLJ44659; FLJ44764; Four repeat voltage gated ion channel; MGC74524; Nalcn; NALCN_HUMAN; Putative 4 repeat voltage gated ion channel; Sodium leak channel non-selective protein; sodium leak channel, non selective; Vgcnl1; VGCNL1 protein; voltage gated channel like 1; Voltage gated channel-like protein 1
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