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The antibody against NCK2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human NCK2 (NP_003572.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NCK2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human NCK2 (NP_003572.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-01964A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NCK2 |
| Target Synonyms | GRB4; NCKbeta; NCK2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293T, Mouse lung | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human NCK2 (NP_003572.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43639 | Immunogen Sequence |
Uniprot Id
O43639
Target Species
Human
Target Name
NCK2
Target Full Name
Cytoplasmic protein NCK2
Target Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Target Subcellular Location
Cytoplasm. Endoplasmic reticulum.
Target Tissue Specificity
Ubiquitous.
Target Research Area
Transcription
Target Synonyms
Cytoplasmic protein NCK2; GRB4; Growth factor receptor bound protein 4; NCK adaptor protein 2; Nck-2; NCK2; NCK2_HUMAN; NCKbeta; Non-catalytic region of tyrosine kinase adaptor protein 2; Noncatalytic region of tyrosine kinase beta; SH2/SH3 adaptor protein NCK-beta
Target Background
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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