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The antibody against NEK4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NEK4 (NP_003148.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NEK4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NEK4 (NP_003148.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00286A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NEK4 |
| Target Synonyms | NRK2; STK2; pp12301; NEK4 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse testis, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NEK4 (NP_003148.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P51957 | Immunogen Sequence |
Uniprot Id
P51957
Target Species
Human
Target Name
NEK4
Target Full Name
Serine/threonine-protein kinase Nek4
Target Function
Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
Target Subcellular Location
Cell projection, cilium. Cytoplasm.
Target Protein Families
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Target Tissue Specificity
Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.
Target Synonyms
NEK4; STK2; Serine/threonine-protein kinase Nek4; EC 2.7.11.1; Never in mitosis A-related kinase 4; NimA-related protein kinase 4; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase NRK2
Target Background
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.
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