Rabbit anti-Human NEK4 Polyclonal Antibody

Uniprot Id

P51957

Target Species

Human

Target Name

NEK4

Target Full Name

Serine/threonine-protein kinase Nek4

Target Function

Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

Target Subcellular Location

Cell projection, cilium. Cytoplasm.

Target Protein Families

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily

Target Tissue Specificity

Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.

Target Synonyms

NEK4; STK2; Serine/threonine-protein kinase Nek4; EC 2.7.11.1; Never in mitosis A-related kinase 4; NimA-related protein kinase 4; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase NRK2

Target Background

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.