Rabbit anti-Human NEK7 Polyclonal Antibody

The antibody against NEK7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 257-301 of human NEK7 (NP_598001.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04363A

Number

Cat.No	ADA-04363A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	NEK7
Form	Liquid	Species Reactivity	Human, Mouse, Rat
Isotype	IgG	Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.
Purification Method	Affinity purification	Positive Samples	HepG2, Jurkat, Mouse lung, Rat liver
Application	ELISA, WB

Cat.No

ADA-04363A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

NEK7

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, Jurkat, Mouse lung, Rat liver

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 257-301 of human NEK7 (NP_598001.1).	Target Species	Human
Immunogen Sequence	PLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTAS	Uniprot ID	Q8TDX7

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 257-301 of human NEK7 (NP_598001.1).

Target Species

Human

Immunogen Sequence

PLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTAS

Uniprot ID

Q8TDX7

Background Information

Uniprot Id

Q8TDX7
Target Species

Human
Target Name

NEK7
Target Full Name

Serine/threonine-protein kinase Nek7
Target Function

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression.
Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Target Tissue Specificity

Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
Target Synonyms

EC 2.7.11.1; NEK7; NEK7_HUMAN; Never in mitosis A-related kinase 7; Never in mitosis gene a-related kinase 7; NIMA (never in mitosis gene a) related kinase 7; NIMA (never in mitosis gene a)-related expressed kinase 7; NimA related protein kinase 7 ; NIMA-related kinase 7; NimA-related protein kinase 7; Serine/threonine-protein kinase Nek7
Target Background

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.

Rabbit anti-Human NEK7 Polyclonal Antibody

Specifications

Immunogen Information

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