Rabbit anti-Human NET1 Polyclonal Antibody

The antibody against NET1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NET1 (NP_001040625.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-02186A

Number

Cat.No	ADA-02186A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	NET1
Target Synonyms	NET1A; ARHGEF8; NET1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, MCF7, Mouse liver, Mouse thymus, SW480	Application	ELISA, WB, IF/ICC

Cat.No

ADA-02186A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

NET1

Target Synonyms

NET1A; ARHGEF8; NET1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, MCF7, Mouse liver, Mouse thymus, SW480

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NET1 (NP_001040625.1).	Target Species	Human
Uniprot ID	Q7Z628	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NET1 (NP_001040625.1).

Target Species

Human

Uniprot ID

Q7Z628

Immunogen Sequence

Background Information

Uniprot Id

Q7Z628
Target Species

Human
Target Name

NET1
Target Full Name

Neuroepithelial cell-transforming gene 1 protein
Target Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Tissue Specificity

Widely expressed.
Target Research Area

Signal Transduction
Target Synonyms

ARHG8_HUMAN; ARHGEF8; GLYT2 ; Guanine nucleotide regulatory protein oncogene; MGC114559 ; MGC127767 ; MGC53602 ; mNET1; Net1; NET1A; Neuroepithelial cell transforming gene 1; Neuroepithelial cell-transforming gene 1 protein; p65 Net1 proto oncogene; Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8; Rho guanine nucleotide exchange factor GEF 8
Target Background

This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Rabbit anti-Human NET1 Polyclonal Antibody

Specifications

Immunogen Information

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