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The antibody against NEURL2 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Neuralized-2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against NEURL2 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Neuralized-2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of K562 cells using Neuralized-2 Polyclonal Antibody
| Cat.No | ADC-38112A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NEURL2 |
| Target Synonyms | NEURL2 antibody; C20orf163 antibody; Neuralized-like protein 2 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Neuralized-2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BR09 |
Uniprot Id
Q9BR09
Target Species
Human
Target Name
NEURL2
Target Full Name
Neuralized-like protein 2
Target Function
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed specifically in skeletal and cardiac muscles.
Target Synonyms
NEURL2; C20orf163; Neuralized-like protein 2
Target Background
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants.
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