Rabbit anti-Human Neurofilament H Monoclonal Antibody

The antibody against Neurofilament H was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 550-650 of human Neurofilament H (P12036) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, IP, ELISA.

ADA-16766A

Number

Cat.No	ADA-16766A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Neurofilament H
Target Synonyms	NFH; CMT2CC; Neurofilament H	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, Mouse brain	Application	ELISA, WB, IF/ICC, IHC-P, IP

Cat.No

ADA-16766A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Neurofilament H

Target Synonyms

NFH; CMT2CC; Neurofilament H

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, Mouse brain

Application

ELISA, WB, IF/ICC, IHC-P, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 550-650 of human Neurofilament H (P12036).	Target Species	Human
Immunogen Sequence	AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE	Uniprot ID	P12036

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 550-650 of human Neurofilament H (P12036).

Target Species

Human

Immunogen Sequence

AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE

Uniprot ID

P12036

Background Information

Uniprot Id

P12036
Target Species

Human
Target Name

NEFH
Target Full Name

Neurofilament heavy polypeptide
Target Function

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Target Involvement

Amyotrophic lateral sclerosis (ALS); Charcot-Marie-Tooth disease 2CC (CMT2CC)
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, axon.
Target Protein Families

Intermediate filament family
Target Research Area

Neuroscience
Target Synonyms

200 kDa neurofilament protein; CMT2CC; Nefh; Neurofilament heavy polypeptide 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; NF H; NF-H; NFH; NFH_HUMAN
Target Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Rabbit anti-Human Neurofilament H Monoclonal Antibody

Specifications

Immunogen Information

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