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The antibody against NFAM1 was raised in rabbit using the Recombinant Human NFAT activation molecule 1 protein (186-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against NFAM1 was raised in rabbit using the Recombinant Human NFAT activation molecule 1 protein (186-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using NFAM1 Antibody at dilution of 1:100
| Cat.No | ADC-18637A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NFAM1 |
| Target Synonyms | NFAM1 antibody; CNAIPNFAT activation molecule 1 antibody; Calcineurin/NFAT-activating ITAM-containing protein antibody; NFAT-activating protein with ITAM motif 1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human NFAT activation molecule 1 protein (186-270AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NET5 |
Uniprot Id
Q8NET5
Target Species
Human
Target Name
NFAM1
Target Full Name
NFAT activation molecule 1
Target Function
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.
Target Synonyms
NFAM1; CNAIPNFAT activation molecule 1; Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1
Target Background
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells.
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