Rabbit anti-Human NFS1 Polyclonal Antibody

Uniprot Id

Q9Y697

Target Species

Human

Target Name

NFS1

Target Full Name

Cysteine desulfurase

Target Function

Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.

Target Subcellular Location

[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm. Nucleus.

Target Protein Families

Class-V pyridoxal-phosphate-dependent aminotransferase family, NifS/IscS subfamily

Target Tissue Specificity

Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas.

Target Synonyms

Cysteine desulfurase; Cysteine desulfurase; mitochondrial ; HUSSY 08 ; IscS; mitochondrial; NFS1; NFS1 nitrogen fixation 1; NFS1 nitrogen fixation 1 homolog (S. cerevisiae); NFS1_HUMAN; NIFS; nitrogen fixation 1 (S. cerevisiae; homolog); nitrogen fixation gene 1; nitrogen-fixing bacteria S; homolog of; nitrogen-fixing bacteria S-like protein; OTTHUMP00000030799

Target Background

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.