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The antibody against NFYB was raised in rabbit using the Recombinant Human Nuclear transcription factor Y subunit beta protein (1-207AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against NFYB was raised in rabbit using the Recombinant Human Nuclear transcription factor Y subunit beta protein (1-207AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human small intestine tissue using NFYB Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human thymus tissue using NFYB Antibody at dilution of 1:1002
| Cat.No | ADC-17281A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NFYB |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Nuclear transcription factor Y subunit beta protein (1-207AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P25208 |
Uniprot Id
P25208
Target Species
Human
Target Name
NFYB
Target Full Name
Nuclear transcription factor Y subunit beta
Target Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Target Subcellular Location
Nucleus.
Target Protein Families
NFYB/HAP3 subunit family
Target Research Area
Signal Transduction
Target Synonyms
CAAT box DNA binding protein subunit B; CAAT box DNA-binding protein subunit B; CBF A; CBF B; CCAAT binding transcription factor subunit A; HAP 3; HAP3; NF Y protein chain B; NF YB; NF-YB; NFYB; NFYB_HUMAN; Nuclear transcription factor Y beta; Nuclear transcription factor Y subunit B; Nuclear transcription factor Y subunit beta; Transcription factor NF Y B subunit
Target Background
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
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