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The antibody against NGB was raised in rabbit using the Recombinant Human Neuroglobin protein (1-151AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against NGB was raised in rabbit using the Recombinant Human Neuroglobin protein (1-151AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49632A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NGB |
| Target Synonyms | Neuroglobin antibody; NGB antibody; NGB_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Neuroglobin protein (1-151AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NPG2 |
Uniprot Id
Q9NPG2
Target Species
Human
Target Name
NGB
Target Full Name
Neuroglobin
Target Function
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Target Subcellular Location
Perikaryon. Cytoplasm. Mitochondrion.
Target Protein Families
Globin family
Target Tissue Specificity
Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.
Target Research Area
Transport
Target Synonyms
Neuroglobin; NGB; NGB_HUMAN
Target Background
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.
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