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The antibody against NGEF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 429-710 of human NGEF (NP_062824.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against NGEF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 429-710 of human NGEF (NP_062824.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00235A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NGEF |
| Target Synonyms | EPHEXIN; ARHGEF27; NGEF | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, PC-3 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 429-710 of human NGEF (NP_062824.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N5V2 | Immunogen Sequence |
Uniprot Id
Q8N5V2
Target Species
Human
Target Name
NGEF
Target Full Name
Ephexin-1
Target Function
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
Target Subcellular Location
Cytoplasm. Membrane. Cell projection, growth cone.
Target Tissue Specificity
Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
Target Synonyms
ARHGEF27; Eph receptor-interacting exchange protein; Eph-interacting exchange protein; EPHEXIN; Ephexin-1; Guanine nucleotide exchange factor, neuronal; Neuronal guanine nucleotide exchange factor; Ngef; NGEF_HUMAN
Target Background
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; ephrin receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse.
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