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The antibody against NIT1 was raised in rabbit using the Recombinant Human Deaminated glutathione amidase protein (1-243AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against NIT1 was raised in rabbit using the Recombinant Human Deaminated glutathione amidase protein (1-243AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-19510A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NIT1 |
| Target Synonyms | MGC57670 antibody; NIT1 antibody; NIT1_HUMAN antibody; Nitrilase 1 antibody; Nitrilase homolog 1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Deaminated glutathione amidase protein (1-243AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86X76 |
Uniprot Id
Q86X76
Target Species
Human
Target Name
NIT1
Target Full Name
Deaminated glutathione amidase
Target Function
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
Target Subcellular Location
[Isoform 2]: Mitochondrion.; [Isoform 1]: Cytoplasm.
Target Protein Families
Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family
Target Tissue Specificity
Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
Target Synonyms
MGC57670 ; NIT1; NIT1_HUMAN; Nitrilase 1; Nitrilase homolog 1
Target Background
This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene.
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