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The antibody against NKIRAS1 was raised in rabbit using the Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against NKIRAS1 was raised in rabbit using the Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using NKIRAS1 Antibody at dilution of 1:1002
| Cat.No | ADC-24263A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NKIRAS1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NYS0 |
Uniprot Id
Q9NYS0
Target Species
Human
Target Name
NKIRAS1
Target Full Name
NF-kappa-B inhibitor-interacting Ras-like protein 1
Target Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Small GTPase superfamily, Ras family, KappaB-Ras subfamily
Target Tissue Specificity
Widely expressed.
Target Synonyms
2400004O09Rik ; I kappa B interacting Ras like protein 1; I-kappa-B-interacting Ras-like protein 1; Kappa B Ras 1; Kappa B Ras protein 1; Kappa B-Ras protein 1; KappaB Ras1; KappaB-Ras1; KBRAS 1; KBRAS1; KBRS1_HUMAN; NF kappa B inhibitor interacting Ras like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras like 1; NFKB inhibitor interacting Ras like protein 1; NKIRAS 1; nkiras1
Target Background
Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum.
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